Preheat your oven to 350°F (175°C).

In a large skillet, brown the ground beef over medium heat until fully cooked. Drain excess fat.

In a mixing bowl, combine the cooked beef, cream of chicken soup, sour cream, garlic powder, onion powder, salt, and black pepper. Mix well.

Stir in half of the crushed Doritos and half of the shredded cheddar cheese.

Transfer the mixture to a greased casserole dish.

Top the casserole with the remaining crushed Doritos and cheddar cheese.

Bake in the preheated oven for 25-30 minutes, or until the cheese is bubbly and golden.

Remove from the oven and let it cool for a few minutes before serving.